NMN treatment downregulated melanin production in aged melanocytes, but not young melanocytesNAD+, an NMN product within the cells, downregu- lated both melanin production and CAMP/Wnt signaling (melanogenesis-as- sociated receptors). ThereforeNMN is a human-friendly anti-melanogenic agent with the potential to aid in aging-related hyperpigmentation
Skin Protection from UVB Impairment
NMN treatment protects human skin cells from UVB impairment effects by enhancing DNA repair, decreasing reactive oxygen species production, decreasing nitric oxide release, and blocking local inflammation
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